TUESDAY, Dec. 8, 2020 — Numerous complications of COVID-19 have been identified, according to a study published online Dec. 8 in CMAJ, the journal of the Canadian Medical Association.

William Murk, Ph.D., M.P.H., from the University at Buffalo in New York, and colleagues examined all possible COVID-19 complications using U.S. health claims data. The frequency of all International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) diagnosis codes occurring before and after the COVID-19 pandemic onset was compared in an exposure-crossover design.

The researchers found that 69 of 1,724 analyzed ICD-10-CM codes were significantly associated with COVID-19 among 70,288 patients with COVID-19. Strong associations with COVID-19 and high absolute risks were seen for disorders such as viral pneumonia (odds ratio, 177.63; absolute risk, 27.6 percent), respiratory failure (odds ratio, 11.36; absolute risk, 22.6 percent), acute kidney failure (odds ratio, 3.50; absolute risk, 11.8 percent), and sepsis (odds ratio, 4.23; absolute risk, 10.4 percent). Strong associations but low absolute risks were seen for disorders including myocarditis (odds ratio, 8.17; absolute risk, 0.1 percent), disseminated intravascular coagulation (odds ratio, 11.83; absolute risk, 0.1 percent), and pneumothorax (odds ratio, 3.38; absolute risk, 0.4 percent).

“Understanding the full range of associated conditions can aid in prognosis, guide treatment decisions, and better inform patients as to their actual risks for the variety of COVID-19 complications reported in the literature and media,” the authors write.

Several authors disclosed financial ties to the health care technology industry.

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