Creutzfeldt-Jakob disease is a rare, degenerative, fatal brain disorder. It affects about 1 person in every 1 million per year worldwide, and about 350 cases are diagnosed per year in the U.S., according to the National Institute of Neurological Disorders and Stroke.
The cause of Creutzfeldt-Jakob disease appears to be abnormal versions of a type of protein called a prion. Normally these proteins are produced in the body and are harmless. But when they’re misshapen, they become infectious and can harm normal biological processes.
Signs and symptoms of Creutzfeldt-Jakob disease can be similar to those of other dementialike brain disorders, such as Alzheimer’s disease. But Creutzfeldt-Jakob disease usually progresses much more rapidly.
Early signs and symptoms typically include:
- Personality changes.
- Memory loss.
- Impaired thinking.
- Blurred vision or blindness.
- Insomnia.
- Incoordination.
- Difficulty speaking.
- Difficulty swallowing.
- Sudden, jerky movements.
As the disease progresses, mental symptoms worsen. Most people eventually fall into a coma. Heart failure, lung failure, pneumonia or other infections are generally the cause of death, which usually occurs within a year.
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