New research has found that individuals born with inherited mutations of the “BLM gene’ are more susceptible to developing mesothelioma, especially upon exposure to asbestos. The study was conducted by University of Hawaiʻi Cancer Center researcher Michele Carbone and collaborators, and was published in the Proceedings of the National Academy of Sciences.

Individuals who inherit two mutated copies of the BLM gene are affected by the rare Bloom Syndrome, characterized by short stature, a red rash over the nose and cheeks, mild immune deficiency and an increased susceptibility to develop various cancers. However, approximately one in every 900 individuals is born with only one inherited mutation of the BLM gene. The cells of these individuals produce only half of the normal amount of BLM protein, which was suspected, and has now been proven, to increase their risk of developing cancer.

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